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Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics
[Image: see text] Ceftaroline, a recently approved β-lactam antibiotic for treatment of infections by methicillin-resistant Staphylococcus aureus (MRSA), is able to inhibit penicillin-binding protein 2a (PBP2a) by triggering an allosteric conformational change that leads to the opening of the active...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210145/ https://ncbi.nlm.nih.gov/pubmed/24955778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5030657 |
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