Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

[Image: see text] Ceftaroline, a recently approved β-lactam antibiotic for treatment of infections by methicillin-resistant Staphylococcus aureus (MRSA), is able to inhibit penicillin-binding protein 2a (PBP2a) by triggering an allosteric conformational change that leads to the opening of the active...

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Main Authors: Fishovitz, Jennifer, Rojas-Altuve, Alzoray, Otero, Lisandro H., Dawley, Matthew, Carrasco-López, Cesar, Chang, Mayland, Hermoso, Juan A., Mobashery, Shahriar
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4210145/
https://ncbi.nlm.nih.gov/pubmed/24955778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5030657
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