Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC-dependence in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver bile duct malignancy exhibiting frequent isocitrate dehydrogenase (IDH1/IDH2) mutations. Through a high-throughput drug screen of a large panel of cancer cell lines including 17 biliary tract cancers, we found that IDH mutant (IDHm) ICC ce...

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Bibliografske podrobnosti
izdano v:Cancer Discov
Main Authors: Saha, Supriya K., Gordan, John D., Kleinstiver, Benjamin P., Vu, Phuong, Najem, Mortada S., Yeo, Jia-Chi, Shi, Lei, Kato, Yasutaka, Levin, Rebecca S., Webber, James T., Damon, Leah J., Egan, Regina K., Greninger, Patricia, McDermott, Ultan, Garnett, Mathew J., Jenkins, Roger L., Rieger-Christ, Kimberly M., Sullivan, Travis B., Hezel, Aram F., Liss, Andrew S., Mizukami, Yusuke, Goyal, Lipika, Ferrone, Cristina R., Zhu, Andrew X., Joung, J. Keith, Shokat, Kevan M., Benes, Cyril H., Bardeesy, Nabeel
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458737/
https://ncbi.nlm.nih.gov/pubmed/27231123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1442
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