Isocitrate dehydrogenase mutations confer dasatinib hypersensitivity and SRC-dependence in intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver bile duct malignancy exhibiting frequent isocitrate dehydrogenase (IDH1/IDH2) mutations. Through a high-throughput drug screen of a large panel of cancer cell lines including 17 biliary tract cancers, we found that IDH mutant (IDHm) ICC ce...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Cancer Discov
Asıl Yazarlar: Saha, Supriya K., Gordan, John D., Kleinstiver, Benjamin P., Vu, Phuong, Najem, Mortada S., Yeo, Jia-Chi, Shi, Lei, Kato, Yasutaka, Levin, Rebecca S., Webber, James T., Damon, Leah J., Egan, Regina K., Greninger, Patricia, McDermott, Ultan, Garnett, Mathew J., Jenkins, Roger L., Rieger-Christ, Kimberly M., Sullivan, Travis B., Hezel, Aram F., Liss, Andrew S., Mizukami, Yusuke, Goyal, Lipika, Ferrone, Cristina R., Zhu, Andrew X., Joung, J. Keith, Shokat, Kevan M., Benes, Cyril H., Bardeesy, Nabeel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5458737/
https://ncbi.nlm.nih.gov/pubmed/27231123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-1442
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