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mTORC1 promotes T-bet phosphorylation to regulate Th1 differentiation
CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFNγ under Th1 polarizing conditions. We hypothesized that this phenotype is due to defects in regulation of the canonical Th1 transcription factor T-bet at the level of protein phosphorylation downstream of mTORC1. To test this hypothes...
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| Publicat a: | J Immunol |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5458608/ https://ncbi.nlm.nih.gov/pubmed/28424242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601078 |
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