Role of the oxidized form of XRCC1 in protection against extreme oxidative stress

The multi-domain protein XRCC1 is without catalytic activity, but can interact with a number of known repair proteins. The interaction between the N-terminal domain (NTD) of XRCC1 and DNA polymerase β (pol β) is critical for recruitment of pol β to sites of DNA damage and repair. Crystallographic an...

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Veröffentlicht in:Free Radic Biol Med
Hauptverfasser: Horton, Julie K., Seddon, Hannah J., Zhao, Ming-Lang, Gassman, Natalie R., Janoshazi, Agnes K., Stefanick, Donna F., Wilson, Samuel H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5457714/
https://ncbi.nlm.nih.gov/pubmed/28179111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.02.005
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