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Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses
Poly(ADP-ribose) polymerase-1 (PARP-1) binds intermediates of base excision repair (BER) and becomes activated for poly(ADP-ribose) (PAR) synthesis. PAR mediates recruitment and functions of the key BER factors XRCC1 and DNA polymerase β (pol β) that in turn regulate PAR. Yet, the molecular mechanis...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3924596/ https://ncbi.nlm.nih.gov/pubmed/23871146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.06.004 |
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