Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses

Poly(ADP-ribose) polymerase-1 (PARP-1) binds intermediates of base excision repair (BER) and becomes activated for poly(ADP-ribose) (PAR) synthesis. PAR mediates recruitment and functions of the key BER factors XRCC1 and DNA polymerase β (pol β) that in turn regulate PAR. Yet, the molecular mechanis...

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Main Authors: Horton, Julie K., Stefanick, Donna F., Gassman, Natalie R., Williams, Jason G., Gabel, Scott A., Cuneo, Matthew. J., Prasad, Rajendra, Kedar, Padmini S., DeRose, Eugene F., Hou, Esther W., London, Robert E., Wilson, Samuel H.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924596/
https://ncbi.nlm.nih.gov/pubmed/23871146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.06.004
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