Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses

Poly(ADP-ribose) polymerase-1 (PARP-1) binds intermediates of base excision repair (BER) and becomes activated for poly(ADP-ribose) (PAR) synthesis. PAR mediates recruitment and functions of the key BER factors XRCC1 and DNA polymerase β (pol β) that in turn regulate PAR. Yet, the molecular mechanis...

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Bibliografische gegevens
Hoofdauteurs: Horton, Julie K., Stefanick, Donna F., Gassman, Natalie R., Williams, Jason G., Gabel, Scott A., Cuneo, Matthew. J., Prasad, Rajendra, Kedar, Padmini S., DeRose, Eugene F., Hou, Esther W., London, Robert E., Wilson, Samuel H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3924596/
https://ncbi.nlm.nih.gov/pubmed/23871146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.06.004
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