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DNA polymerase β-dependent cell survival independent of XRCC1 expression

Base excision repair (BER) is a primary mechanism for repair of base lesions in DNA such as those formed by exposure to the DNA methylating agent methyl methanesulfonate (MMS). Both DNA polymerase β (pol β)- and XRCC1-deficient mouse fibroblasts are hypersensitive to MMS. This is linked to a repair...

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Détails bibliographiques
Publié dans:DNA Repair (Amst)
Auteurs principaux: Horton, Julie K., Gassman, Natalie R., Dunigan, Brittany B., Stefanick, Donna F., Wilson, Samuel H.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4308486/
https://ncbi.nlm.nih.gov/pubmed/25541391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.11.008
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