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DNA polymerase β-dependent cell survival independent of XRCC1 expression
Base excision repair (BER) is a primary mechanism for repair of base lesions in DNA such as those formed by exposure to the DNA methylating agent methyl methanesulfonate (MMS). Both DNA polymerase β (pol β)- and XRCC1-deficient mouse fibroblasts are hypersensitive to MMS. This is linked to a repair...
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| Veröffentlicht in: | DNA Repair (Amst) |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4308486/ https://ncbi.nlm.nih.gov/pubmed/25541391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2014.11.008 |
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