A conserved NAD(+) binding pocket that regulates protein-protein interactions during aging

DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD(+) (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate pr...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Li, Jun, Bonkowski, Michael S., Moniot, Sébastien, Zhang, Dapeng, Hubbard, Basil P., Ling, Alvin J. Y., Rajman, Luis A., Qin, Bo, Lou, Zhenkun, Gorbunova, Vera, Aravind, L., Steegborn, Clemens, Sinclair, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5456119/
https://ncbi.nlm.nih.gov/pubmed/28336669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad8242
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