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Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol
Sirtuins are NAD(+)-dependent protein deacetylases regulating metabolism, stress responses and ageing processes. Among the seven mammalian Sirtuins, Sirt1 is the physiologically best-studied isoform. It regulates nuclear functions such as chromatin remodelling and gene transcription, and it appears...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3654483/ https://ncbi.nlm.nih.gov/pubmed/23548308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120121 |
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