Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol

Sirtuins are NAD(+)-dependent protein deacetylases regulating metabolism, stress responses and ageing processes. Among the seven mammalian Sirtuins, Sirt1 is the physiologically best-studied isoform. It regulates nuclear functions such as chromatin remodelling and gene transcription, and it appears...

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Hlavní autoři: Lakshminarasimhan, Mahadevan, Curth, Ute, Moniot, Sebastien, Mosalaganti, Shyamal, Raunser, Stefan, Steegborn, Clemens
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2013
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654483/
https://ncbi.nlm.nih.gov/pubmed/23548308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20120121
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