Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells

The overexpression of P-glycoprotein (P-gp) causes resistance to chemotherapy in many tumor types. Here, we report intercellular transfer of functional P-gp from P-gp-positive to P-gp-negative cells in vitro and in vivo. The expression of acquired P-gp is transient in isolated cells but persists in...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Levchenko, Andre, Mehta, Bipin M., Niu, Xinle, Kang, Grace, Villafania, Liliana, Way, Denise, Polycarpe, Dolores, Sadelain, Michel, Larson, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC545583/
https://ncbi.nlm.nih.gov/pubmed/15671173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401851102
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker