Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells

The overexpression of P-glycoprotein (P-gp) causes resistance to chemotherapy in many tumor types. Here, we report intercellular transfer of functional P-gp from P-gp-positive to P-gp-negative cells in vitro and in vivo. The expression of acquired P-gp is transient in isolated cells but persists in...

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Bibliographic Details
Main Authors: Levchenko, Andre, Mehta, Bipin M., Niu, Xinle, Kang, Grace, Villafania, Liliana, Way, Denise, Polycarpe, Dolores, Sadelain, Michel, Larson, Steven M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC545583/
https://ncbi.nlm.nih.gov/pubmed/15671173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401851102
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