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Intercellular transfer of P-glycoprotein mediates acquired multidrug resistance in tumor cells
The overexpression of P-glycoprotein (P-gp) causes resistance to chemotherapy in many tumor types. Here, we report intercellular transfer of functional P-gp from P-gp-positive to P-gp-negative cells in vitro and in vivo. The expression of acquired P-gp is transient in isolated cells but persists in...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545583/ https://ncbi.nlm.nih.gov/pubmed/15671173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401851102 |
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