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Thermodynamic prediction of protein neutrality
We present a simple theory that uses thermodynamic parameters to predict the probability that a protein retains the wild-type structure after one or more random amino acid substitutions. Our theory predicts that for large numbers of substitutions the probability that a protein retains its structure...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC545518/ https://ncbi.nlm.nih.gov/pubmed/15644440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406744102 |
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