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Why highly expressed proteins evolve slowly
Much recent work has explored molecular and population-genetic constraints on the rate of protein sequence evolution. The best predictor of evolutionary rate is expression level, for reasons that have remained unexplained. Here, we hypothesize that selection to reduce the burden of protein misfoldin...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1242296/ https://ncbi.nlm.nih.gov/pubmed/16176987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504070102 |
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