Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E

Cholesteryl ester transfer protein (CETP) mediates the transfer of HDL cholesteryl esters for triglyceride (TG) in VLDL/LDL. CETP inhibition, with anacetrapib, increases HDL-cholesterol, reduces LDL-cholesterol, and lowers TG levels. This study describes the mechanisms responsible for TG lowering by...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Lipid Res
Auteurs principaux: Millar, John S., Lassman, Michael E., Thomas, Tiffany, Ramakrishnan, Rajasekhar, Jumes, Patricia, Dunbar, Richard L., deGoma, Emil M., Baer, Amanda L., Karmally, Wahida, Donovan, Daniel S., Rafeek, Hashmi, Wagner, John A., Holleran, Stephen, Obunike, Joseph, Liu, Yang, Aoujil, Soumia, Standiford, Taylor, Gutstein, David E., Ginsberg, Henry N., Rader, Daniel J., Reyes-Soffer, Gissette
Format: Artigo
Langue:Inglês
Publié: The American Society for Biochemistry and Molecular Biology 2017
Sujets:
Patient-Oriented and Epidemiological Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454510/
https://ncbi.nlm.nih.gov/pubmed/28314859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M074880
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