Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E

Cholesteryl ester transfer protein (CETP) mediates the transfer of HDL cholesteryl esters for triglyceride (TG) in VLDL/LDL. CETP inhibition, with anacetrapib, increases HDL-cholesterol, reduces LDL-cholesterol, and lowers TG levels. This study describes the mechanisms responsible for TG lowering by...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Millar, John S., Lassman, Michael E., Thomas, Tiffany, Ramakrishnan, Rajasekhar, Jumes, Patricia, Dunbar, Richard L., deGoma, Emil M., Baer, Amanda L., Karmally, Wahida, Donovan, Daniel S., Rafeek, Hashmi, Wagner, John A., Holleran, Stephen, Obunike, Joseph, Liu, Yang, Aoujil, Soumia, Standiford, Taylor, Gutstein, David E., Ginsberg, Henry N., Rader, Daniel J., Reyes-Soffer, Gissette
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2017
Subjects:
Patient-Oriented and Epidemiological Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454510/
https://ncbi.nlm.nih.gov/pubmed/28314859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M074880
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