Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E

Cholesteryl ester transfer protein (CETP) mediates the transfer of HDL cholesteryl esters for triglyceride (TG) in VLDL/LDL. CETP inhibition, with anacetrapib, increases HDL-cholesterol, reduces LDL-cholesterol, and lowers TG levels. This study describes the mechanisms responsible for TG lowering by...

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Publicado en:J Lipid Res
Autores principales: Millar, John S., Lassman, Michael E., Thomas, Tiffany, Ramakrishnan, Rajasekhar, Jumes, Patricia, Dunbar, Richard L., deGoma, Emil M., Baer, Amanda L., Karmally, Wahida, Donovan, Daniel S., Rafeek, Hashmi, Wagner, John A., Holleran, Stephen, Obunike, Joseph, Liu, Yang, Aoujil, Soumia, Standiford, Taylor, Gutstein, David E., Ginsberg, Henry N., Rader, Daniel J., Reyes-Soffer, Gissette
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2017
Materias:
Patient-Oriented and Epidemiological Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454510/
https://ncbi.nlm.nih.gov/pubmed/28314859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M074880
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