CETP inhibition with Anacetrapib Decreases Fractional Clearance Rates of HDL Apolipoprotein A-I and Plasma CETP

OBJECTIVE: Anacetrapib, an inhibitor of cholesteryl ester transfer protein (CETP) activity, increases plasma concentrations of HDL-C, apoA-I, apoA-II, and CETP. The mechanisms responsible for these treatment-related increases in apolipoproteins and plasma CETP are unknown. We performed a randomized,...

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Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Reyes-Soffer, Gissette, Millar, John S., Ngai, Colleen, Jumes, Patricia, Coromilas, Ellie, Asztalos, Bela, Johnson-Levonas, Amy O., Wagner, John A., Donovan, Daniel S., Karmally, Wahida, Ramakrishnan, Rajasekhar, Holleran, Stephen, Thomas, Tiffany, Dunbar, Richard L., deGoma, Emil M., Rafeek, Hashmi, Baer, Amanda L., Liu, Yang, Lassman, Michael E., Gutstein, David E., Rader, Daniel J., Ginsberg, Henry N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4911016/
https://ncbi.nlm.nih.gov/pubmed/26966279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306680
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