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Phagocytosis enhances lysosomal and bactericidal properties by activating the transcription factor TFEB

Macrophages internalize pathogens through phagocytosis, entrapping them into organelles called phagosomes. Phagosomes then fuse with lysosomes to mature into phagolysosomes, acquiring an acidic and hydrolytic lumen that kills the pathogens. During an ongoing infection, macrophages can internalize do...

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Foilsithe in:Curr Biol
Main Authors: Gray, Matthew A., Choy, Christopher H., Dayam, Roya M., Escobar, Erika O., Somerville, Alexander, Xiao, Xuan, Ferguson, Shawn M., Botelho, Roberto J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453720/
https://ncbi.nlm.nih.gov/pubmed/27397893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2016.05.070
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