Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy. They also play an important role in sensing and instructing cells on their metabolic state. The lipid kinase PIKfyve generates phosphatidylinositol-3,5-bisphosphate to modulate lysosome function. PIKfyve inhibition lea...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cell Sci
Egile Nagusiak: Choy, Christopher H., Saffi, Golam, Gray, Matthew A., Wallace, Callen, Dayam, Roya M., Ou, Zhen-Yi A., Lenk, Guy, Puertollano, Rosa, Watkins, Simon C., Botelho, Roberto J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Company of Biologists Ltd 2018
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031331/
https://ncbi.nlm.nih.gov/pubmed/29661845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.213587
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