Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy. They also play an important role in sensing and instructing cells on their metabolic state. The lipid kinase PIKfyve generates phosphatidylinositol-3,5-bisphosphate to modulate lysosome function. PIKfyve inhibition lea...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Choy, Christopher H., Saffi, Golam, Gray, Matthew A., Wallace, Callen, Dayam, Roya M., Ou, Zhen-Yi A., Lenk, Guy, Puertollano, Rosa, Watkins, Simon C., Botelho, Roberto J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031331/
https://ncbi.nlm.nih.gov/pubmed/29661845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.213587
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