Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence

Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy. They also play an important role in sensing and instructing cells on their metabolic state. The lipid kinase PIKfyve generates phosphatidylinositol-3,5-bisphosphate to modulate lysosome function. PIKfyve inhibition lea...

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Dettagli Bibliografici
Pubblicato in:J Cell Sci
Autori principali: Choy, Christopher H., Saffi, Golam, Gray, Matthew A., Wallace, Callen, Dayam, Roya M., Ou, Zhen-Yi A., Lenk, Guy, Puertollano, Rosa, Watkins, Simon C., Botelho, Roberto J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2018
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6031331/
https://ncbi.nlm.nih.gov/pubmed/29661845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.213587
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