Tristetraprolin expression by keratinocytes controls local and systemic inflammation

Tristetraprolin (TTP, encoded by the Zfp36 gene) regulates the mRNA stability of several important cytokines. Due to the critical role of this RNA-binding protein in the control of inflammation, TTP deficiency leads to the spontaneous development of a complex inflammatory syndrome. So far, this phen...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Andrianne, Mathieu, Assabban, Assiya, La, Caroline, Mogilenko, Denis, Salle, Delphine Staumont, Fleury, Sébastien, Doumont, Gilles, Van Simaeys, Gaëtan, Nedospasov, Sergei A., Blackshear, Perry J., Dombrowicz, David, Goriely, Stanislas, Van Maele, Laurye
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453703/
https://ncbi.nlm.nih.gov/pubmed/28570274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92979
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