Structural Study of a Flexible Active Site Loop in Human Indoleamine 2,3-Dioxygenase and Its Functional Implications

Human indoleamine 2,3-dioxygenase catalyzes the oxidative cleavage of tryptophan to N-formyl kynurenine, the initial and rate-limiting step in the kynurenine pathway. Additionally, this enzyme has been identified as a possible target for cancer therapy. A 20-amino acid protein segment (the JK loop),...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Álvarez, Lucía, Lewis-Ballester, Ariel, Roitberg, Adrián, Estrin, Darío A., Yeh, Syun-Ru, Marti, Marcelo A., Capece, Luciana
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5450165/
https://ncbi.nlm.nih.gov/pubmed/27112409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00077
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