TDP-43 suppresses tau expression via promoting its mRNA instability

In the brains of individuals with Alzheimer's disease (AD) and chronic traumatic encephalopathy, tau pathology is accompanied usually by intracellular aggregation of transactive response DNA-binding protein 43 (TDP-43). However, the role of TDP-43 in tau pathogenesis is not understood. Here, we...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Gu, Jianlan, Wu, Feng, Xu, Wen, Shi, Jianhua, Hu, Wen, Jin, Nana, Qian, Wei, Wang, Xinglong, Iqbal, Khalid, Gong, Cheng-Xin, Liu, Fei
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449590/
https://ncbi.nlm.nih.gov/pubmed/28335005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx175
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