TDP-43 suppresses tau expression via promoting its mRNA instability

In the brains of individuals with Alzheimer's disease (AD) and chronic traumatic encephalopathy, tau pathology is accompanied usually by intracellular aggregation of transactive response DNA-binding protein 43 (TDP-43). However, the role of TDP-43 in tau pathogenesis is not understood. Here, we...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Gu, Jianlan, Wu, Feng, Xu, Wen, Shi, Jianhua, Hu, Wen, Jin, Nana, Qian, Wei, Wang, Xinglong, Iqbal, Khalid, Gong, Cheng-Xin, Liu, Fei
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449590/
https://ncbi.nlm.nih.gov/pubmed/28335005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx175
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