A selectivity filter at the intracellular end of the acid-sensing ion channel pore

Increased extracellular proton concentrations during neurotransmission are converted to excitatory sodium influx by acid-sensing ion channels (ASICs). 10-fold sodium/potassium selectivity in ASICs has long been attributed to a central constriction in the channel pore, but experimental verification i...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Lynagh, Timothy, Flood, Emelie, Boiteux, Céline, Wulf, Matthias, Komnatnyy, Vitaly V, Colding, Janne M, Allen, Toby W, Pless, Stephan A
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2017
Sujets:
Biophysics and Structural Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449180/
https://ncbi.nlm.nih.gov/pubmed/28498103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24630
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