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Identification of function-regulating antibodies targeting the receptor protein tyrosine phosphatase sigma ectodomain

Receptor tyrosine phosphatase sigma (RPTPσ) plays an important role in the regulation of axonal outgrowth and neural regeneration. Recent studies have identified two RPTPσ ligands, chondroitin sulfate proteoglycans (CSPGs) and heparan sulfate proteoglycans (HSPG), which can modulate RPTPσ activity b...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wu, Chia-Lun, Hardy, Serge, Aubry, Isabelle, Landry, Melissa, Haggarty, Allison, Saragovi, Horacio Uri, Tremblay, Michel L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5449173/
https://ncbi.nlm.nih.gov/pubmed/28558026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178489
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