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A phospholipid sensor controls mechanogating of the K(+) channel TREK-1
TREK-1 (KCNK2 or K(2P)2.1) is a mechanosensitive K(2P) channel that is opened by membrane stretch as well as cell swelling. Here, we demonstrate that membrane phospholipids, including PIP(2), control channel gating and transform TREK-1 into a leak K(+) conductance. A carboxy-terminal positively char...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2005
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC544907/ https://ncbi.nlm.nih.gov/pubmed/15577940 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600494 |
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