A phospholipid sensor controls mechanogating of the K(+) channel TREK-1

TREK-1 (KCNK2 or K(2P)2.1) is a mechanosensitive K(2P) channel that is opened by membrane stretch as well as cell swelling. Here, we demonstrate that membrane phospholipids, including PIP(2), control channel gating and transform TREK-1 into a leak K(+) conductance. A carboxy-terminal positively char...

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Dades bibliogràfiques

Publicat a:	EMBO J
Autors principals:	Chemin, Jean, Patel, Amanda Jane, Duprat, Fabrice, Lauritzen, Inger, Lazdunski, Michel, Honoré, Eric
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2004
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544907/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15577940/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600494
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