A phospholipid sensor controls mechanogating of the K(+) channel TREK-1
TREK-1 (KCNK2 or K(2P)2.1) is a mechanosensitive K(2P) channel that is opened by membrane stretch as well as cell swelling. Here, we demonstrate that membrane phospholipids, including PIP(2), control channel gating and transform TREK-1 into a leak K(+) conductance. A carboxy-terminal positively char...
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| Опубліковано в:: | EMBO J |
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| Автори: | , , , , , |
| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Nature Publishing Group
2004
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| Предмети: | |
| Онлайн доступ: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544907/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15577940/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600494 |
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