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2-Aminoethoxydiphenyl borate activates the human mechano-gated KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK) and KCNK 10 (TREK-2).

Abstract: Two-pore domain K+ (KCNK, K2P) channels underlie the leak (background) potassium conductance in many types of excitable cells. They oppose membrane depolarization and cell excitability. These channels have been reported to be modulated by several physical and chemical stimuli. The compound...

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Autores principales: Leopoldo Raul Beltran, Madeline eBeltran, Ainhara eAguado, Guenter eGisselmann, Hanns eHatt
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2013-05-01
Colección:Frontiers in Pharmacology
Materias:
2-APB
KCNK channels
TREK
Xenopus oocytes
two-electrode voltage clamp
Acceso en línea:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00063/full
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