Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death

The endoplasmic reticulum, the cytoplasmic organelle that matures a massive amount of nascent secretory polypeptides, is particularly sensitive to stress. Endoplasmic reticulum stress causes unfolded proteins to populate the organelle, eliciting the unfolded protein response. During the unfolded pro...

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Publicado en:Nat Commun
Main Authors: Pinkaew, Decha, Chattopadhyay, Abhijnan, King, Matthew D., Chunhacha, Preedakorn, Liu, Zhihe, Stevenson, Heather L., Chen, Yanjie, Sinthujaroen, Patuma, McDougal, Owen M., Fujise, Ken
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446404/
https://ncbi.nlm.nih.gov/pubmed/28550308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00029-1
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