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Human Fortilin Is A Molecular Target of Dihydroartemisinin
Dehydroartemisinin (DHA) is an effective anti-malaria agent. Fortilin is an anti-apoptotic molecule overexpressed in many human cancers. Here, we show that DHA binds human fortilin, increases the ubiquitination of fortilin, shortens fortilin’s half-life in a proteasome-dependent fashion, and reduces...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2727609/ https://ncbi.nlm.nih.gov/pubmed/18325342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.02.055 |
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