Physical and Functional Antagonism between Tumor Suppressor Protein p53 and Fortilin, an Anti-apoptotic Protein

Tumor suppressor protein p53, our most critical defense against tumorigenesis, can be made powerless by mechanisms such as mutations and inhibitors. Fortilin, a 172-amino acid polypeptide with potent anti-apoptotic activity, is up-regulated in many human malignancies. However, the exact mechanism by...

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Hlavní autoři: Chen, Yanjie, Fujita, Takayuki, Zhang, Di, Doan, Hung, Pinkaew, Decha, Liu, Zhihe, Wu, Jiaxin, Koide, Yuichi, Chiu, Andrew, Lin, Curtis Chen-Jen, Chang, Jui-Yoa, Ruan, Ke-He, Fujise, Ken
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173145/
https://ncbi.nlm.nih.gov/pubmed/21795694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217836
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