Fortilin potentiates the peroxidase activity of Peroxiredoxin-1 and protects against alcohol-induced liver damage in mice

Fortilin, a pro-survival molecule, inhibits p53-induced apoptosis by binding to the sequence-specific DNA-binding domain of the tumor suppressor protein and preventing it from transcriptionally activating Bax. Intriguingly, fortilin protects cells against ROS-induced cell death, independent of p53....

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Pubblicato in:Sci Rep
Autori principali: Chattopadhyay, Abhijnan, Pinkaew, Decha, Doan, Hung Q., Jacob, Reed B., Verma, Sunil K., Friedman, Hana, Peterson, Alan C., Kuyumcu-Martinez, Muge N., McDougal, Owen M., Fujise, Ken
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4698670/
https://ncbi.nlm.nih.gov/pubmed/26726832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18701
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