Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters

DNA (cytosine-5)-methyltransferase (DNMT) 1 participates in transcriptional repression of genes by methylation-dependent and -independent mechanisms. Here, DNMT1 is shown to bind p53 and colocalize in the nucleus. DNMT1-mediated methylation is stimulated by p53 in vitro. Upon p53 induction, a report...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Estève, Pierre-Olivier, Chin, Hang Gyeong, Pradhan, Sriharsa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2005
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC544618/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15657147/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0407729102
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