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Aneuploidy in Cancer and Aging

Chromosomal instability (CIN), the persistent inability of a cell to faithfully segregate its genome, is a feature of many cancer cells. It stands to reason that CIN enables the acquisition of multiple cancer hallmarks; however, there is a growing body of evidence suggesting that CIN impairs cellula...

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Foilsithe in:Annu Rev Genet
Main Authors: Naylor, Ryan M., van Deursen, Jan M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445725/
https://ncbi.nlm.nih.gov/pubmed/27893964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-genet-120215-035303
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