Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase Ldt(Mt2) by biapenem and tebipenem

BACKGROUND: The carbapenem subclass of β-lactams is among the most potent antibiotics available today. Emerging evidence shows that, unlike other subclasses of β-lactams, carbapenems bind to and inhibit non-classical transpeptidases (L,D-transpeptidases) that generate 3 → 3 linkages in bacterial pep...

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Detalhes bibliográficos
Publicado no:BMC Biochem
Main Authors: Bianchet, Mario A., Pan, Ying H., Basta, Leighanne A. Brammer, Saavedra, Harry, Lloyd, Evan P., Kumar, Pankaj, Mattoo, Rohini, Townsend, Craig A., Lamichhane, Gyanu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445500/
https://ncbi.nlm.nih.gov/pubmed/28545389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12858-017-0082-4
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