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Loss of a Functionally and Structurally Distinct ld-Transpeptidase, Ldt(Mt5), Compromises Cell Wall Integrity in Mycobacterium tuberculosis
The final step of peptidoglycan (PG) biosynthesis in bacteria involves cross-linking of peptide side chains. This step in Mycobacterium tuberculosis is catalyzed by ld- and dd-transpeptidases that generate 3→3 and 4→3 transpeptide linkages, respectively. M. tuberculosis PG is predominantly 3→3 cross...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4646210/ https://ncbi.nlm.nih.gov/pubmed/26304120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.660753 |
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