Loss of a Functionally and Structurally Distinct ld-Transpeptidase, Ldt(Mt5), Compromises Cell Wall Integrity in Mycobacterium tuberculosis

The final step of peptidoglycan (PG) biosynthesis in bacteria involves cross-linking of peptide side chains. This step in Mycobacterium tuberculosis is catalyzed by ld- and dd-transpeptidases that generate 3→3 and 4→3 transpeptide linkages, respectively. M. tuberculosis PG is predominantly 3→3 cross...

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Pubblicato in:J Biol Chem
Autori principali: Brammer Basta, Leighanne A., Ghosh, Anita, Pan, Ying, Jakoncic, Jean, Lloyd, Evan P., Townsend, Craig A., Lamichhane, Gyanu, Bianchet, Mario A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646210/
https://ncbi.nlm.nih.gov/pubmed/26304120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.660753
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