Non-classical transpeptidases yield insight into new antibacterials

Bacterial survival requires an intact peptidoglycan layer, a 3-dimensional exoskeleton that encapsulates the cytoplasmic membrane. Historically, the final steps of peptidoglycan synthesis are known to be carried out by d,d-transpeptidases, enzymes that are inhibited by the β-lactams which constitute...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Chem Biol
Päätekijät: Kumar, Pankaj, Kaushik, Amit, Lloyd, Evan P., Li, Shao-Gang, Mattoo, Rohini, Ammerman, Nicole C., Bell, Drew T., Perryman, Alexander L., Zandi, Trevor A., Ekins, Sean, Ginell, Stephan L., Townsend, Craig A., Freundlich, Joel S., Lamichhane, Gyanu
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477059/
https://ncbi.nlm.nih.gov/pubmed/27820797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2237
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