Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression

The human growth hormone (hGH) minigene used for transgene stabilization in mice has been recently identified to be locally expressed in the tissues where transgenes are active and associated with phenotypic alterations. Here we extend these findings by analyzing the effect of the hGH minigene in Tg...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Kaklamanos, Aimilios, Rozman, Jan, Roulis, Manolis, Karagianni, Niki, Armaka, Maria, Wu, Moya, Brachthäuser, Laura, Calzada-Wack, Julia, Horsch, Marion, Beckers, Johannes, Rathkolb, Birgit, Adler, Thure, Neff, Frauke, Wolf, Eckhard, Gailus-Durner, Valerie, Fuchs, Helmut, de Angelis, Martin Hrabe, Kollias, George
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5445072/
https://ncbi.nlm.nih.gov/pubmed/28546545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02581-8
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