Intestinal epithelial cells as producers but not targets of chronic TNF suffice to cause murine Crohn-like pathology

TNF plays a crucial role in the pathogenesis of Crohn disease. Dysregulated TNF production in mice that bear the genetic deletion of the TNF AU-rich regulatory elements (ARE) (Tnf(ΔARE/+) mice) results in TNF receptor I (TNFRI)-dependent spontaneous Crohn-like pathology. Current concepts consider in...

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Bibliographic Details
Main Authors: Roulis, Manolis, Armaka, Maria, Manoloukos, Menelaos, Apostolaki, Maria, Kollias, George
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069201/
https://ncbi.nlm.nih.gov/pubmed/21402942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1007811108
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