Genetic Dissection of the Cellular Pathways and Signaling Mechanisms in Modeled Tumor Necrosis Factor–induced Crohn's-like Inflammatory Bowel Disease

Recent clinical evidence demonstrated the importance of tumor necrosis factor (TNF) in the development of Crohn's disease. A mouse model for this pathology has previously been established by engineering defects in the translational control of TNF mRNA (Tnf (Δ) (ARE)mouse). Here, we show that de...

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Auteurs principaux: Kontoyiannis, Dimitris, Boulougouris, George, Manoloukos, Menelaos, Armaka, Maria, Apostolaki, Maria, Pizarro, Theresa, Kotlyarov, Alexey, Forster, Irmgard, Flavell, Richard, Gaestel, Matthias, Tsichlis, Philip, Cominelli, Fabio, Kollias, George
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2002
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196068/
https://ncbi.nlm.nih.gov/pubmed/12486099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020281
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