Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology

Interleukin-10 (IL-10) is a key inhibitory signal of inflammatory responses that regulates the production of potentially pathogenic cytokines like tumor necrosis factor (TNF). We show here that the development of chronic intestinal inflammation in IL-10-deficient mice requires the function of TNF, i...

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Main Authors: Kontoyiannis, Dimitris, Kotlyarov, Alexey, Carballo, Ester, Alexopoulou, Lena, Blackshear, Perry J., Gaestel, Matthias, Davis, Roger, Flavell, Richard, Kollias, George
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2001
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC125555/
https://ncbi.nlm.nih.gov/pubmed/11447117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.14.3760
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