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LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP

The production of the proinflammatory cytokines TNF-α and IL-6 is regulated by various mRNA-binding proteins, influencing stability and translation of the respective transcripts. Research in macrophages has shown the importance of the p38-MK2-tristetraprolin (TTP) axis for regulation of TNF-α mRNA s...

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Dettagli Bibliografici
Pubblicato in:Cell Signal
Autori principali: Hochdörfer, Thomas, Tiedje, Christopher, Stumpo, Deborah J., Blackshear, Perry J., Gaestel, Matthias, Huber, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784419/
https://ncbi.nlm.nih.gov/pubmed/23499908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.02.022
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