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LPS-induced production of TNF-α and IL-6 in mast cells is dependent on p38 but independent of TTP

The production of the proinflammatory cytokines TNF-α and IL-6 is regulated by various mRNA-binding proteins, influencing stability and translation of the respective transcripts. Research in macrophages has shown the importance of the p38-MK2-tristetraprolin (TTP) axis for regulation of TNF-α mRNA s...

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Détails bibliographiques
Publié dans:Cell Signal
Auteurs principaux: Hochdörfer, Thomas, Tiedje, Christopher, Stumpo, Deborah J., Blackshear, Perry J., Gaestel, Matthias, Huber, Michael
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784419/
https://ncbi.nlm.nih.gov/pubmed/23499908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2013.02.022
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